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本实验通过OEXA和ABC免疫组化分别测定9、18和27月龄组大鼠的骨密度和胫骨干骺端的P物质．结果为9、18和27月组的大鼠骨密度（g／Cm1）分别为0．2827±0．0188、0．3303±0.0288和O．2619±0．0322，P物质是（＋＋）、（＋＋＋＋）和（＋＋＋＋）．表明大鼠在27月龄已处于老化，骨密度减少，而P物质随增龄而增加，骨密度与P物质之间无明显相关性．本文认为骨衰老早期骨密度无明显变化，此期骨组织中的P物质已有量的改变，对早期预测骨衰老有一定启示作用．
In this study, bone mineral density and substance P in the metaphysis of tibia were measured by OEXA and ABC immunohistochemistry in 9, 18 and 27 month old rats respectively. Results The bone mineral density (g / cm) of rats in the 9th, 18th and 27th month groups were 0.2827 ± 0.0188,0.3303 ± 0.0288 and 0. 2619 ± 0.0322, Substance P is (++), (++++) and (++++). The results showed that the rats aged at 27 months of age had decreased bone mineral density, whereas substance P increased with aging, and there was no significant correlation between bone mineral density and substance P levels. This paper argues that there is no obvious change in bone mineral density in early stage of bone aging. The amount of substance P in bone tissue during this period has a certain amount of change, which has certain enlightenment on the early prediction of bone aging.