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目的:探讨代谢异常病史与遗忘型轻度认知功能障碍(aMCI)的关系。方法:136名患者被分为遗忘型轻度认知功能障碍(aMCI)组(n=93)与对照组(n=43)。对两组患者进行代谢病史的回顾性分析,同时以干化学法检测空腹血糖(FBG)、糖化血红蛋白(HbA1c),以酶联免疫吸附法检测白介素-6(IL-6)。结果:糖尿病史、高血压史及男性吸烟史在两组之间具有统计学差异(P<0.05);高脂血症史、总体吸烟史在两组之间无统计学差异(P>0.05);FBG及HbA1c水平在两组之间无显著性差异;aM-CI组IL-6的水平[(78.57±2.37)pg/ml]显著高于对照组[(72.48±4.74)pg/ml,P<0.05]。结论:高血压、糖尿病、男性吸烟史等危险因素可能通过IL-6相关的炎症状态参与aMCI的发生与发展。
Objective: To investigate the relationship between the history of metabolic abnormalities and amnestic mild cognitive impairment (aMCI). Methods: One hundred and sixty-six patients were divided into amnestic mild cognitive dysfunction (aMCI) group (n = 93) and control group (n = 43). The metabolic history of the two groups were retrospectively analyzed. Fasting blood glucose (FBG) and HbA1c were detected by dry chemical method and interleukin-6 (IL-6) by enzyme-linked immunosorbent assay. Results: The history of diabetes mellitus, history of hypertension and male smoking history were statistically different between the two groups (P <0.05). There was no significant difference between the two groups in history of hyperlipidemia and general smoking (P> 0.05) ; The level of IL-6 in aM-CI group [(78.57 ± 2.37) pg / ml] was significantly higher than that in the control group [(72.48 ± 4.74) pg / ml, P <0.05]. Conclusion: Risk factors such as hypertension, diabetes and smoking history may be involved in the occurrence and development of aMCI through IL-6-related inflammatory state.