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目的:探讨血清脂联素水平与2型糖尿病的相关性。方法:在江苏地区选取新确诊2型糖尿病病例348例,正常对照574例。通过询问和体格检查获取健康状况和生活习惯等资料,采用ELISA法检测血清脂联素水平。结果:2型糖尿病组血清脂联素水平(6.01±2.43)mg/L低于对照组(8.59±2.88)mg/L,其差异有统计学意义(t=14.08,P=0.000);分层分析表明,在不同特征群体中,与血清脂联素高水平者相比,低水平者(小于中位数水平)患2型糖尿病的风险都显著增高,且年龄≤50岁[OR(95%CI):13.80(5.48～34.74)]、吸烟[10.74(5.58～20.68)]、腹型肥胖[7.27(4.55～11.62)]低水平者的OR值居前3位;多因素Logistic回归分析显示,低水平脂联素可能是2型糖尿病的危险因子,血清脂联素水平每降低一个等级(以四分位间距划分等级),发病的风险逐渐增加[OR(95%CI):2.22(1.91～2.58)]。结论:低水平脂联素与2型糖尿病的易感性风险增高之间存在关联。
Objective: To investigate the correlation between serum adiponectin level and type 2 diabetes. Methods: 348 cases of newly diagnosed type 2 diabetes mellitus were selected in Jiangsu Province, 574 cases of normal control. Through interrogation and physical examination for health status and lifestyle information, serum adiponectin levels were measured by ELISA. Results: Serum adiponectin levels in type 2 diabetic patients were significantly lower than those in controls (6.01 ± 2.43 mg / L vs 8.59 ± 2.88 mg / L, t = 14.08, P = 0.000) The analysis showed that the risk of type 2 diabetes was significantly higher in patients with low (less than median) levels compared with those with high levels of adiponectin in different population characteristics and were less than 50 years old [OR (95% CI: 13.80 (5.48-34.74)], smoking (10.74 (5.58-20.68)] and abdominal obesity (7.27 (4.55-11.62)] were among the top three ORs. Multivariate Logistic regression analysis showed that, Low-level adiponectin may be a risk factor for type 2 diabetes with a lower risk of adiposity (OR (95% CI): 2.22 (1.91 ~ 2.58)]. Conclusion: There is a correlation between the low level of adiponectin and the increased risk of type 2 diabetes.