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解放军医学杂志,2015,40(5):415~419.急性高原病(acute mountain sickness,AMS)是指人员由平原进入高原或由高原进入更高海拔地区,在短期内(数小时至数日)发生的各种临床症候群,其发病率高、危害大,是影响快速进入高海拔地区人员身体健康和生命安全的主要疾病。低氧是初入高原时最先被机体感受、也是对机体影响最为严重的环境因子。低氧环境使血管内皮细胞处于病理状态下,功能发生紊乱,分泌的各种调节因子失衡。高原低氧环境可能引起一氧化氮(NO)和前列环素(epoprostenol,PGI2)的合成和释放量减少,
People’s Liberation Army Medical College, 2015,40 (5): 415 ~ 419. Acute mountain sickness (AMS) refers to the movement of personnel from the plain to the plateau or from the plateau to the higher altitude. In the short term (hours to days ) Of the occurrence of various clinical syndromes, its high incidence and great harm, is to affect the rapid entry of personnel in high altitude health and life-threatening major diseases. Hypoxia is the first body to experience when entering the plateau, but also the most serious environmental impact on the body factor. Hypoxic environment so that vascular endothelial cells in the pathological state, dysfunction, secretion of a variety of regulatory imbalance. High altitude hypoxic environment may cause the synthesis and release of nitric oxide (NO) and prostacyclin (PGI2)