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应用免疫组化SP法检测40例肝细胞癌(HCC)组织及正常肝组织中整合素αⅤ、β3的表达。结果:HCC中整合素αⅤ和β3表达阳性率分别为80%、72.5%,均显著高于正常肝组织(44.4%,P<0.05),其表达强度也明显高于正常肝组织(P<0.05)。HCC中整合素αⅤ、β3的表达强度与肿瘤大小及转移密切相关(P<0.05),整合素αⅤ的表达强度与肿瘤包膜侵犯密切相关(P<0.05)。认为整合素αⅤ、β3的在HCC的发生、发展及浸润、转移过程中发挥着重要作用。
Immunohistochemical SP method was used to detect the expression of integrin αⅤ and β3 in 40 cases of hepatocellular carcinoma (HCC) and normal liver tissues. Results: The positive rates of integrin αⅤ and β3 in HCC were 80% and 72.5%, respectively, which were significantly higher than those in normal liver tissues (44.4%, P <0.05) ). The expression of integrin αⅤ and β3 in HCC was closely related to tumor size and metastasis (P <0.05). The expression of integrin αⅤ was closely related to tumor invasion (P <0.05). It is believed that integrin α V and β 3 play an important role in the occurrence, development, infiltration and metastasis of HCC.