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近年来随着广谱抗生素、肾上腺皮质激素、免疫抑制剂等的应用和一些大手术的开展,深部真菌病的发病率有不断增高的趋势,因此,有效地控制深部真菌病具有重要临床上意义。临床上虽出现了许多新的抗真菌药物,尽管它们的毒性作用似乎比两性霉索B低,但从临床疗效来评价,还不能超过或取代两性霉索B。因此,在抗全身性真菌病中两性霉素B仍为首选药。因两性霉素B毒性大,常难以完成疗程,所以我们对其脂质体进行了研究,所制备的脂质体是以天然磷脂质为膜材的
In recent years, with the application of broad-spectrum antibiotics, adrenal cortical hormone, immunosuppressive agents and some major operations, the incidence of deep mycosis is on the rise. Therefore, it is of great clinical significance to effectively control deep mycosis . Although many new antifungal agents have appeared clinically, their toxic effects seem to be lower than that of amphotericin B, but their clinical efficacy should not exceed or replace Amphotericin B. Therefore, amphotericin B is still the preferred drug in combating systemic mycosis. Due to amphotericin B toxicity, often difficult to complete the course of treatment, so we conducted a study of its liposomes, liposomes prepared by the natural phospholipid membrane material