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目的探讨乳腺癌中Galectin-3蛋白的表达情况及其与临床病理特征与分子亚型的关系。方法采用免疫组化法检测标本中Galectin-3的表达水平。结果 Galectin-3蛋白在乳腺癌组织中及淋巴结转移者中表达增高,且随着组织学分级、临床分期的升高而升高。其表达率在基底细胞亚型高于管腔A型,ER阴性组高于ER阳性组。结论 Galectin-3蛋白参与乳腺癌的发生发展,通过检测有助于对乳腺癌预后及分子亚型的判断,为指导临床激素治疗提供参考。
Objective To investigate the expression of Galectin-3 protein in breast cancer and its relationship with clinicopathological features and molecular subtypes. Methods Immunohistochemistry was used to detect the expression of Galectin-3 in the specimens. Results The expression of Galectin-3 protein in breast cancer and lymph node metastasis increased, and with the histological grade, clinical stage increased. The expression rate of basal cell subtype was higher than that of luminal A type, ER negative group was higher than that of ER positive group. Conclusion Galectin-3 protein is involved in the development of breast cancer. It may be helpful to guide the clinical hormone therapy by detecting the prognosis and molecular subtypes of breast cancer.