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目的探讨泌乳素腺瘤患者伽玛刀治疗后早期内分泌功能的变化规律及意义。方法对有完整近期随访资料的27例患者进行回顾分析,调查其临床症状和泌乳素(prolactin,PRL)水平在治疗后6个月的动态变化,并评估该变化可能的临床意义。结果在随访的6个月中,临床症状短暂或持续好转者24例(89%),PRL水平短暂或持续降低21例(78%)。临床症状好转和PRL下降主要发生于治疗后前2个月。临床症状好转率及PRL水平在治疗后前2个月与其他月份间比较有显著差异(P<0.05)。结论泌乳素腺瘤伽玛刀治疗后内分泌功能紊乱的改善在2个月内更为显著,应被视为育龄女性着孕或避孕的重点时期之一。
Objective To investigate the regularity and significance of endocrine function in patients with prolactinoma after gamma knife treatment. Methods A total of 27 patients with complete follow-up data were retrospectively analyzed. The clinical symptoms and the changes of prolactin (PRL) levels at 6 months after the treatment were investigated. The possible clinical significance of the changes was evaluated. Results In the 6 months follow-up, 24 patients (89%) had short-term or continuous improvement of clinical symptoms and 21 patients (78%) had short or continuous PRL. Clinical symptoms improved and PRL decline occurred mainly in the first 2 months after treatment. The rate of improvement of clinical symptoms and PRL levels in the first 2 months after treatment compared with other months were significantly different (P <0.05). Conclusions The improvement of endocrine disorders after prolactinoma gamma knife treatment is more significant within 2 months and should be considered as one of the key periods of pregnancy or contraception for women of childbearing age.