论文部分内容阅读
目的 :探讨HP感染和NSAID在胃粘膜损伤中的相互作用。方法 :对 198例胃十二指肠疾病患者 ,其中 5 4例有口服NSAID病史 ,对所有患者进行纤维胃镜检查 ,并进行HP快速尿素酶试验及血清抗HP -IgG抗体检测 ,根据HP阳性或阴性分为两组。结果 :5 4例口服NSAID患者中HP阳性者 2 2例 ,HP阴性者 3 2例 ,阳性组与阴性组比较 ,十二指肠溃疡发病率明显增高( 5 4 5 % ) ,两组比较差异有显著性。而浅表性胃炎 ,胃粘膜糜烂及粘膜下出血和胃溃疡的发生率两组比较无显著性差异。 14 4例未服NSAID的患者中 ,HP阳性者 5 0例 ,HP阴性者 94例 ,阳性组与阴性组比较 ,十二指肠溃疡的发病率也明显增高 ( 2 8 0 % )。在口服NSAID和未服NSAID的HP阳性病人中 ,十二指肠溃疡的发病率比较差异有显著性。结论 :HP感染可以增加口服NSAID患者十二指肠溃疡发生的危险性 ,HP感染和NSAID在致十二指肠溃疡的发病机制中可能存在协同作用。
Objective: To investigate the interaction between HP infection and NSAID in gastric mucosal lesion. Methods: A total of 198 patients with gastroduodenal diseases were enrolled. Among them, 54 patients had oral history of NSAID. All patients underwent gastroscopy and HP fast urease test and serum anti-HP-IgG antibody test. According to HP positive or Negative divided into two groups. Results: There were 22 HP positive cases and 32 negative HP cases in 54 NSAID patients. The incidence of duodenal ulcer in the positive group was significantly higher than that in the negative group (54.5%). There was significant difference between the two groups Significant. The superficial gastritis, gastric mucosal erosion and submucosal hemorrhage and gastric ulcer incidence was no significant difference between the two groups. Among 14 4 patients who did not receive NSAID, 50 were positive for HP and 94 were negative for HP. The incidence of duodenal ulcer was also significantly higher in the positive group than in the negative group (280%). The incidence of duodenal ulcer was significantly different between oral NSAID and non-NSAID-positive HP-positive patients. Conclusion: HP infection may increase the risk of duodenal ulcer in patients with oral NSAID. There may be synergistic effect between HP infection and NSAID in the pathogenesis of duodenal ulcer.