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105只大鼠0.6—0.9mg/kgT2毒素sc给毒,半数以上动物在给毒后20h内死亡,此后死亡动物很少。26只大鼠0.6—2.4mg/kg T2sc给毒后6h活杀尸检,肉眼所见的主要病变为小肠和脾出血及胸腺萎缩。病理组织学观察可见肠粘膜、淋巴器官、造血组织和睾丸造精组织的拟放射损伤。T2引起的病变特点是:消化道病变发生早,修复快;骨髓损伤可伴有骨组织增生;睾丸损伤不仅累及曲精小管,而且还累及间质;给毒后24h内可查见肝细胞损伤。
105 rats 0.6-0.9mg / kgT2 toxin sc poisoning, more than half of the animals died within 20h after giving the poison, then few died animals. Twenty-six rats, 0.6-2.4mg / kg, were killed by autopsy at 6 hours after T2sc injection. The main pathological changes were small intestine and spleen hemorrhage and thymus atrophy. Histopathological examination showed intestinal epithelial cells, lymphoid organs, hematopoietic tissues and testis spermatogenic tissue pseudo-radiation injury. Pathological changes caused by T2 are: early gastrointestinal lesions, repair faster; bone marrow injury can be associated with bone tissue proliferation; testicular injury not only involving the seminiferous tubules, but also involving the stroma; 24h after poisoning can be found in liver cell injury .