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目的分析2005～2010年江西省疑似预防接种异常反应(AEFI)的发生特征,评价AEFI监测系统运转情况,预防接种服务质量和疫苗的安全性。方法通过中国疑似预防接种异常反应信息管理系统,收集截止2011年4月30日江西省报告的2005～2010年AEFI个案数据,采用描述性方法对相关指标进行流行病学分析。结果全省6年来共收到AEFI个案1703例,≥8岁组占30.42%;其次为﹤1岁组占23.78%;男女性别比为1.61︰1;2009年10～12月、2010年1月、5月和9月例数较多;总报告例数居前5位的分别是麻疹疫苗、甲型H1N1流感疫苗、乙肝(酵母)疫苗、无细胞和全细胞百白破疫苗;临床损害以发热/红肿/硬结和过敏反应为主;71.46%的AEFI在接种后1d内发生;AEFI分类诊断中一般反应占62.24%,异常反应占27.95%。结论监测数据表明,2005～2010年江西省AEFI监测工作取得了非常显著的进步,但监测系统的敏感性仍待进一步提高。江西省AEFI发生流行病学特征与疫苗接种剂次数呈正相关,疫苗安全性和预防接种服务质量较好。
Objective To analyze the occurrence characteristics of suspected AEFI in Jiangxi Province from 2005 to 2010, evaluate the operation of AEFI monitoring system, and prevent vaccination service and vaccine safety. Methods Through the information management system of suspected anaphylaxis in China, the AEFI data collected from April 2005 to April 2010 in Jiangxi Province as of April 30, 2011 were collected, and the descriptive method was used to analyze the epidemiological indexes. Results A total of 1703 AEFI cases were received in the province over the past six years, accounting for 30.42% of the patients aged ≥8 years, followed by 23.78% of the patients aged <1 years, with a sex ratio of 1.61: 1 between January and December 2009 and January 2010 , And the number of cases was higher in May and September. The top five reported cases were measles vaccine, influenza A (H1N1) vaccine, hepatitis B (yeast) vaccine, cell-free and whole cell diphtheriae vaccine; Fever, inflamed / induration and allergic reaction, 71.46% of AEFI occurred within 1 day after inoculation, 62.24% of general reaction in diagnosis of AEFI, and 27.95% of abnormal reaction. Conclusion The monitoring data show that the AEFI monitoring in Jiangxi Province made significant progress in 2005-2010, but the sensitivity of the monitoring system needs to be further improved. Epidemiological characteristics of AEFI in Jiangxi Province were positively correlated with the number of vaccination agents, and the vaccine safety and vaccination services were of good quality.