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我们遇到4例使用灭滴灵后出现精神症状,现将4例报告如下。 例1 男,46岁。1989年元月15日入院。诊断“慢性胆囊炎急性发作”。入院前无社会心理应激因素,既往无精神病史。静脉滴注灭滴灵(2.0/日)两天出现话多,爱管闲事,情绪高。查无意识障碍和神经系统体征。立即停用灭滴灵并输液。口服奋乃静8mg/日。1周后精神症状明显好转,情绪稳定。随访1月目前已正常上班。 例2 男,21岁。1989年元月31日入院。诊断“急性阑尾炎”。既往身体健康,精神状态正常。静脉滴注灭滴灵(2.0/日)4天出现情绪焦虑,失眠,话多管闲事。查无意识障碍及神经系统体征。停用灭滴灵后五天情绪稳定。随访2个月目前精神状态良好,已经上班。 例3 男,58岁。1989年5月9日入院。诊断
We encountered four cases of mental symptoms after the use of metronidazole, now 4 cases are reported below. Example 1 male, 46 years old. January 15, 1989 admission. Diagnosis “Chronic cholecystitis acute attack.” No psychosocial stress factors before admission, no past history of mental illness. Intravenous metronidazole (2.0 / day) appeared more than two days, meddlesome, emotional high. Check for unconsciousness and nervous system signs. Immediately disable metronidazole and infusion. Perphenazine oral 8mg / day. Psychological symptoms improved significantly after 1 week, emotional stability. Follow-up January has now normal work. Example 2 male, 21 years old. January 31, 1989 admission. Diagnosis of “acute appendicitis.” Past physical health, mental state is normal. Intravenous metronidazole (2.0 / day) 4 days of emotional anxiety, insomnia, then sit on the tube. Check for unconsciousness and nervous system signs. Five days after the withdrawal of metronidazole emotional stability. 2 months of follow-up At present, the mental state is good and has been on duty. Example 3 male, 58 years old. May 9, 1989 admission. diagnosis