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最近,Illinois 大学的 Sagen 等采用肾上腺嗜铬细胞脑移植的方法,试图改变病觉感受。选用肾上腺嗜铬细胞作为移植物是由于这些细胞可释放去甲肾上腺素、肾上腺素、甲硫-脑啡肽、亮-脑啡肽及其它神经肽等活性物质,从而作用于中枢神经系统调节痛敏。达些活性物质的释放可被类似于尼古丁样的药物激活。首先将成年大鼠的肾上腺髓质组织颗粒或牛肾上腺嗜铬细胞定位注入大鼠中脑中央导水管周围灰质部位,然后分别在1、2、4和8周时间内皮下注射低剂量尼古丁(0.1mg/kg)以刺激移植细胞释放神经活性物质;
Recently, Sagen of the University of Illinois and others used a method of adrenal chromaffin cell brain transplantation in an effort to alter the perception of the disease. The use of adrenal chromaffin cells as implants is due to the release of norepinephrine, epinephrine, methylthio-enkephalin, enkephalin and other neuropeptides in these cells, which act in the central nervous system to regulate pain Min. The release of some actives can be activated by nicotine-like drugs. Firstly, the adrenal medulla tissue particles or bovine adrenal chromaffin cells of adult rats were implanted into the perinuclear central periaqueductal gray matter of rats, then subcutaneous injection of low doses of nicotine (0.1 mg / kg) to stimulate the transplanted cells to release neuroactive substances;