论文部分内容阅读
克托洛拉是非类固醇类抗炎药(NSAID),其镇痛机制是抑制环氧酶,阻断前列腺素的生物合成。克托洛拉的镇痛效果和吗啡相当,对呼吸和循环功能无影响,抑制血小板聚集,但不增加手术出血量。本文介绍克托洛拉的临床药理学及围术期应用。
Ketorolase is a non-steroidal anti-inflammatory drug (NSAID) whose analgesic mechanism is to inhibit cyclooxygenase and block prostaglandin biosynthesis. Ketorolac has the same analgesic effect as morphine, has no effect on respiratory and circulatory function, inhibits platelet aggregation but does not increase the amount of surgical bleeding. This article describes the clinical pharmacology and perioperative application of ketorolac.