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目的：进一步确定成人Ｔ细胞白血病／淋巴瘤（ＡＴＬＬ）外周血淋巴细胞形态学特征及其鉴别诊断。方法：用外周血离心涂片法对１０例ＡＴＬＬ（急性型８例，淋巴瘤型２例）、７例ＴｎｏｎＨｏｄｋｉｎ淋巴瘤（ＴＮＨＬ）、４例Ｈｏｄｋｉｎ病（ＨＤ）、１５例ＢＮＨＬ、７例淋巴结反应性增生（ＲＨ）、５例实体瘤和１０例正常人淋巴细胞形态进行了观察，用聚合酶链反应（ＰＣＲ）法对所有ＡＴＬＬ、ＴＮＨＬ和部分ＨＤ和ＲＨ患者进行了ＨＴＬＶⅠ前病毒ＤＮＡ检测，并将ＡＴＬＬ与上述其他疾病的临床和实验室进行了比较。结果：几乎所有ＡＴＬＬ、特别是急性型患者均可发现大量肿瘤细胞，其主要特点是：①核呈分叶状或花瓣状和呈深大切迹；②核呈多形性，表现为折叠扭曲、脑回状和瘤状突起等；③可见个别巨大细胞。约半数以上ＴＮＨＬ、ＢＮＨＬ和ＨＤ患者可见少量肿瘤细胞，ＲＨ患者可见异形淋巴细胞。上述疾病的临床表现有重叠之处。结论：用离心涂片法可以比较容易地发现和辨认典型的ＡＴＬＬ细胞，但当细胞形态不典型时，仅凭形态学检查还不够，仍有赖于病理、免疫组化和ＨＴＬＶⅠ前病毒ＤＮＡ的检测
Objective: To further determine the morphological features and differential diagnosis of peripheral blood lymphocytes in adult T-cell leukemia/lymphoma (ATLL). METHODS: Ten patients with ATLL (8 acute cases, 2 lymphoma cases), 7 TnonHodkin lymphomas (TNHL), 4 Hodkin’s disease (HD), 15 were treated with peripheral blood centrifuge smears. Case B-NHL, 7 cases of lymph node reactive hyperplasia (RH), 5 cases of solid tumors, and 10 normal human lymphocyte morphology were observed. All the ATLL, T-NHL, and some HD were evaluated by polymerase chain reaction (PCR). HTLV-I proviral DNA detection was performed in patients with RH, and ATLL was compared with the clinical and laboratory of other diseases mentioned above. RESULTS: A large number of tumor cells were found in almost all patients with ATLL, especially in acute patients. The main features were: 1 The nucleus was lobulated or petal-shaped and showed a deep notch; 2 The nucleus was polymorphic, showing folding distortion, Brain gyrus and nodules; 3 can see individual giant cells. More than half of patients with TNHL, BNHL, and HD had a small number of tumor cells, and patients with RH had abnormal lymphocytes. The clinical manifestations of these diseases overlap. Conclusion: The typical ATLL cells can be easily found and identified by the centrifugal smear method. However, when the morphology of the cells is not typical, morphological examination alone is not sufficient. It still depends on pathology, immunohistochemistry and HTLV-I proviral DNA. Detection