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为探讨ｐ５３和ｃ－ｍｙｃ基因异常表达与膀胱癌多药耐药性（ＭＤＲ）的关系，应用ＡＢＣ免疫组织化学方法检测６７例膀胱癌癌细胞中ｐ５３和ｃ－ｍｙｃ的表达产物及多药耐药基因（ｍｄｒ－１）产物Ｐ－ｇｐ。结果显示ｐ５３突变蛋白蓄积的膀胱癌中Ｐ－ｇｐ阳性表达率９２．３％；ｐ５３阴性者Ｐ－ｇｐ阳性率为３６．６％。Ｐ－ｇｐ表达与ｐ５３突变蛋白蓄积呈显著正相关（ｒ＝０．６４，Ｐ＜０．０５）；而ｃ－ｍｙｃ和ｍｄｒ－１的表达无明显相关。提示：ｐ５３异常表达可增加ｍｄｒ－１基因的表达，使膀胱癌细胞获得ＭＤＲ表型
To investigate the relationship between abnormal expression of p53 and c-myc genes and multidrug resistance (MDR) in bladder cancer, the expression products and multidrug resistance of p53 and c-myc in 67 bladder cancer cells were detected by ABC immunohistochemistry. Drug gene (mdr-1) product P-gp. The results showed that the positive expression rate of P-gp was 92.3% in the bladder cancer with accumulation of p53 mutant protein; the positive rate of P-gp in p53-negative patients was 36.6%. There was a significant positive correlation between the expression of P-gp and the accumulation of p53 mutein (r=0.64, P<0.05). However, there was no significant correlation between the expression of c-myc and mdr-1. Tip: Abnormal expression of p53 can increase the expression of mdr-1 gene and make bladder cancer cells acquire MDR phenotype.