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虽然急性心包炎是重型β地中海贫血的一种常见并发症,但还没有人调查研究过这种病中心肌炎的患病率和后果。 方法和结果 作者对全部重型β地中海贫血病人进行预期5年随访研究,这些重型β地中海贫血中的急性感染性心肌炎的诊断已能在1977年和1986年间确定。作者也对相同年龄和性别配对对照β地中海贫血病人随访5年,这些病人左室功能正常无心肌炎依据。在1048例重型β地中海贫血中,伴有心前区胸痛的47例(年龄,15±2.5岁)被诊断为患有急性感染性心肌炎。心肌活组织检查诊断26例,可疑14例,排除7例。11例(23.4％)伴心肌炎病人发生伴左室功能障
Although acute pericarditis is a common complication of severe beta thalassemia, no one has investigated the prevalence and consequences of myocarditis in this disease. METHODS AND RESULTS The authors of the prospective, 5-year follow-up study of all patients with β-thalassemia major had a diagnosis of acute infectious myocarditis in these β-thalassemia major, which was established between 1977 and 1986. The authors also followed up for 5 years in matched controls of β-thalassemia patients of the same age and gender, who were normal without myocarditis based on their left ventricular function. Of the 1048 cases of beta-thalassemia major, 47 cases (age, 15 2.5 years) with chest pain in the anterior chamber area were diagnosed as having acute infectious myocarditis. Myocardial biopsy diagnosis of 26 cases, 14 cases of doubt, excluding 7 cases. 11 cases (23.4%) with myocarditis patients with left ventricular dysfunction