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目的：对人胰腺癌中转化生长因子β1（TGF－β1）及其血型受体（TβRⅡ）的表达进行研究，探讨其与胰腺癌进展、转移的关系。方法：应用SABC免疫组化方法检测TGF－βl、TβR－Ⅱ在10例正常胰腺，13例慢性胰腺炎和36例胰腺癌中的表达。结果：1．TGF－β1、TβⅡ阳性率在正常胰腺均为10．0％，慢性胰腺炎中分别为7．7％、15．4％，胰腺癌中分别为44．4％、47．2％，胰腺癌中的阳性率明显高于前两组（P＜0．05））；2．TGF－β1、TβRⅡ的表达与胰腺癌患者的年龄、性别、肿瘤的大小、位置、组织学分级无关（P＞005），与临床分期相关（P＜0．001）；3．TGF－β1、TβRⅡ在胰腺癌中共同阳性率为36．1％，其共同表达与胰腺癌的组织学分级和临床分期有关（P＜0．001）。结论：单独检测TGF－βl、TβRⅡ的表达对判断胰腺癌的进展、转移趋势有参考价值；二者共同表达对判断胰腺癌的恶性程度及进展、转移趋势有参考价值。
OBJECTIVE: To investigate the expression of transforming growth factor-β1 (TGF-β1) and its blood type receptor (TβRII) in human pancreatic cancer and to explore its relationship with the progression and metastasis of pancreatic cancer. Methods: SABC immunohistochemical method was used to detect the expression of TGF-β1 and TβR-II in 10 cases of normal pancreas, 13 cases of chronic pancreatitis and 36 cases of pancreatic cancer. Results: 1. The positive rate of TGF-β1 and TβII was 10.0% in normal pancreas, 7.7% and 15.4% in chronic pancreatitis, and 44.4% and 47.2% in pancreatic cancer. The positive rate was significantly higher in the two groups (P<0.05); 2. The expression of TGF-β1 and TβRII was not associated with age, gender, size, location and histological grade of pancreatic cancer patients (P>005), but was correlated with clinical stage (P<0.001). The common positive rate of TGF-β1 and TβRII in pancreatic cancer was 36.1%, and their co-expression was related to the histological grade and clinical stage of pancreatic cancer (P<0.001). Conclusions: The expression of TGF-β1 and TβRII alone can be used as a reference for judging the progression and metastasis of pancreatic cancer. The co-expression of TGF-β1 and TβRII may be useful for judging the malignancy, progression and metastasis of pancreatic cancer.