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[Objective]To investigate the effect of three processing techniques of hot milk-impregnated-processing,cold milk-impregnatedprocessing and hot sand method on the contents of strychnine and brucine extracted from Semen strychni,so as to providing scientific basis for explaining the rationality of using milk-impregnated-processing technique to treat toxic materials in traditional Uighur medicines. [Methods]Employing strychnine and brucine as indicators,the hot milk-impregnated-processing and cold milk-impregnated-processing techniques used in Uighur medicine and the hot sand method used in Chinese medicine were adopted to process Semen strychni,and the optimal processing technique was obtained by comparing the contents of strychnine and brucine in processed and crude Semen strychni materials. [Results]The influence of each processing technique on strychnine and brucine was in turn hot milk-impregnated-processing > cold milk-impregnated-processing >hot sand method. The hot sand method did not effectively reduce the content of strychnine and brucine in crude Semen strychni,while both hot milk-impregnated-processing and cold milk-impregnated-processing did. In comparison with the crude materials,milk-impregnated-processingtechnology could influence the content of strychnine and brucine significantly( P < 0. 05,P < 0. 01 or P < 0. 001). [Conclusions] The hot milk-impregnated-processing technique used in traditional Uighur medicines can remarkably reduce the content of strychnine and brucine in crude Semen strychni,providing scientific basis for the use of milk-impregnated-processing technique to treat toxic materials in traditional Uighur medicines.
[Objective] To investigate the effect of three processing techniques of hot milk-impregnated-processing, cold milk-impregnated processing and hot sand method on the contents of strychnine and brucine extracted from Semen strychni, so as to for scientific basis for explaining the rationality of using milk-impregnated-processing technique to treat toxic materials in traditional Uighur medicines. [Methods] Employing strychnine and brucine as indicators, the hot milk-impregnated-processing and cold milk-impregnated-processing techniques used in Uighur medicine and the hot sand method used in Chinese medicine were adopted to process Semen strychni, and the optimal processing technique was obtained by comparing the contents of strychnine and brucine in processed and crude Semen strychni materials. [Results] The influence of each processing technique on strychnine and brucine was in turn hot milk-impregnated-processing> cold milk-impregnated-processing> hot sand method. The hot sand method did not effectively reduce the content of strychnine and brucine in crude Semen strychni, while both hot milk-impregnated-processing and cold milk-impregnated-processing did. In comparison with the crude materials, milk-impregnated-processing technology could influence the content of strychnine and brucine significantly (P <0.05, P <0.01 or P <0.001). [Conclusions] The hot milk-impregnated-processing technique used in traditional Uighur medicines can remarkably reduce the content of strychnine and brucine in crude Semen strychni, providing scientific basis for the use of milk-impregnated-processing technique to treat toxic materials in traditional Uighur medicines.