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１９４６年Ｃｈａｓｅ和Ｓｕｌｔｚｂｅｒｇｅｒ发现预先口服一种抗原，可诱导机体对此抗原产生免疫耐受，这一现象被称为Ｃｈａｓｅ和Ｓｕｌｔｚｂｅｒｇｅｒ效应［１］。随后的研究表明，肝脏在免疫调节中发挥重要的作用，经门静脉预先行抗原的接种（ｐｏｒｔａｌｖｅｎ...
In 1946, Chase and Sultzberger found that pre-oral administration of an antigen induces the body to become immune tolerant to this antigen, a phenomenon known as the Chase and Sultzberger effect [1]. Subsequent studies have shown that the liver plays an important role in immune regulation, portal vein pre-antigens inoculation (portalven ...