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由结扎左前降冠状动脉尖支的方法造成犬的心肌梗塞,用心外膜电图标测术评价中药红花提取液对心肌缺血程度的影响。本研究发现,红花液显著减少心外膜电图标测点ST段平均抬高程度,这种变化尤以梗塞边缘区为甚。红花液还可明显减少梗塞边缘区ST段显著抬高的标测点数。输入红花液后,心率及张力—时间指数明显减少。说明红花可以挽救梗塞边缘区濒危缺血心肌而缩小急性冠脉闭塞后的梗塞范围,这种有益作用可能与其降低心肌耗氧量有关。
The dog’s myocardial infarction was caused by ligation of the left anterior descending coronary artery branch, and the epicardial electrical icon test was used to evaluate the effect of the Chinese medicine Honghua extract on the degree of myocardial ischemia. This study found that safflower liquid significantly reduced the ST-segment elevation of epicardial electrograms, especially in the marginal region of the infarct. Safflower fluid can also significantly reduce the number of mapping points in the ST segment of the infarct marginal area. After entering safflower fluid, heart rate and tension-time index decreased significantly. It is concluded that safflower can rescue the infarcted ischemic myocardium and reduce the infarct size after acute coronary occlusion. This beneficial effect may be related to the decrease of myocardial oxygen consumption.