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前列腺素(PG)是一种广泛分布于机体内的生物活性物质,其研究不断深入。1967年Coceani 等观察到有PG 排入胃液,并注意到PG 与消化性溃疡有关,同年,Robert,等提出PG 有细胞保护作用,从而使PG 与消化性溃疡关系的研究进入了一个新阶段。以有细胞保护作用为特征的PGE 作为一种防御因子增强剂治疗消化性溃疡,近年来取得了可喜进展。一、前列腺素与胃肠粘膜PG 由不饱和脂肪酸组成,其前体为花生四烯酸。胃肠粘膜的PG 含量较高,仅次于肾脏和
Prostaglandin (PG) is a widely distributed bioactive substances in the body, its research continues to deepen. In 1967, Coceani et al observed that PG was released into the gastric juice and noted that PG was associated with peptic ulcer. In the same year, Robert et al. Proposed that PG should have cytoprotective effects and thus entered a new stage in the study of the relationship between PG and peptic ulcer. In recent years, PGE as a defensive factor enhancer for the treatment of peptic ulcer has been promising. First, prostaglandin and gastrointestinal mucosa PG consists of unsaturated fatty acids, its precursor is arachidonic acid. Gastrointestinal mucosa PG content higher, second only to the kidneys and