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左旋和右旋吡喹酮治疗大鼠华支睾吸虫感染,总剂量均为400mg/kg,二日疗法,于治疗后7天解剖结果,左旋吡喹酮组治愈率为100％;右旋喹喹酮组和对照组每鼠平均回收虫数分别为6.6±2.72与8.47±5.97条。左旋吡喹酮的疗效明显优于右旋吡喹酮(P<0.01)。右旋吡喹酮和对照组比较无显著差异(P>0.05)。现场治疗华支睾吸虫病37例,左旋吡喹酮总剂量为75mg/kg(25mg/kg一日3次×1天)。治疗后3个月虫卵阴转率为71.88％(23/32),未阴转者9例,平均减卵率为98.6％。药物副作用轻而短暂,血、尿常规,肝功能试验和心电图检查治疗前后对比均比明显改变。
L and praziquantel treatment of Clonorchis sinensis in rats, the total dose were 400mg / kg, two days treatment, 7 days after treatment, the results of the anteversion, praziquantel group cure rate was 100% The average number of worms recovered in the quercetin and control groups was 6.6 ± 2.72 and 8.47 ± 5.97, respectively. The effect of L-praziquantel was better than that of praziquantel (P <0.01). There was no significant difference between praziquantel and control group (P> 0.05). In situ treatment of clonorchiasis in 37 cases, the total dose of praziquantel was 75mg / kg (25mg / kg a day × 1 day). Three months after treatment, the conversion rate of oviparous eggs was 71.88% (23/32), and 9 cases were not overcast. The average egg reduction rate was 98.6%. Drug side effects of light and short, blood, urine, liver function tests and ECG before and after treatment compared to the obvious changes.