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合用抗酸剂对甲氰眯胍生物利用度的影响已经过多次研究。有些人报告并不降低甲氰眯胍的生物利用度,而另些人则证明甲氰咪胍的吸收程度明显减少。后者的研究使用甲氰咪胍的单剂量口服。这种混乱促使研究合用抗酸剂对重复给药时血浆甲氰咪胍浓度的影响,这是模拟了发生在消化性溃疡病人实际治疗中的条件。 12名健康受试者随机、对照、交叉分组进行试验。每名受试者被分期给予下面两种疗法:(a)甲氰咪胍300mg与240ml水
The effect of co-antacids on the bioavailability of memantine has been studied many times. Some report that they do not reduce the bioavailability of squinomycin while others show a significant reduction in the absorption of cimetidine. The latter study used a single oral dose of cimetidine. This confusion prompted the study of combined antacids on plasma cidimetidine concentrations at repeated doses, which mimicked the conditions that actually occur in patients with peptic ulcer disease. Twelve healthy subjects were randomized, controlled, crossover trials. Each subject was staged for the following two therapies: (a) Cimetidine 300 mg and 240 ml water