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本文报道了肝病状态下药物排出率的变化,并给出五种主要的药动学变量(清除率、分布量、消除半衰期、未结合药物百分率及生物利用度)。从实用的立场出发,这些指标中最重要的是清除率,根据清除率即可决定该药物的用药剂量方案。在稳定状态下(即给药速率与药物排出速率相等时),若知道了某种药物的总体清除率(CL)及所期望的该药物在稳定状态下的血浆或全血浓度(C_(SS)),即可根据下述公式算出该药物的给药速率:
This paper reports the changes of drug excretion rate in the presence of liver disease, and gives five main pharmacokinetic variables (clearance, distribution, elimination half-life, unbound drug percentage and bioavailability). From a practical standpoint, the most important of these indicators is the clearance rate, which determines the dosing schedule for the drug based on clearance rates. At steady state (ie, at the same dosing rate as the rate of drug excretion), if one knows the overall clearance (CL) for a drug and the expected plasma or whole blood concentration of the drug at steady state (C_ (SS )), You can calculate the drug administration rate according to the following formula: