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利用家免多器官功能障碍综合征（MODS）模型观察维生素E（VitE）对血管内皮细胞的保护作用。采用内皮细胞形态观察并同步检测血液MDA、SOD、CAT、TXB2、6－K－PGFIα以及应用VitE后对其影响。结果示MODS组动物血中MDA和TXB2含量随MODS的发生发展显著升高（P＜0．01），而SOD、CAT及6－K－PGFIα含量降低（P＜0．01）。利用扫描和透射电镜观察MODS血管内皮细胞发生显著损伤，失去正常形态；而补充VitE组前述各项指标均得到不同程度的改善．观察结果提示，MODS动物体内脂质过氧化损伤明显增强，而抗氧化能力明尼降低。这种变化可能在MODS发病中具有重要的病理生理意义。早期应用VitE对MODS的防治是有益的。
To observe the protective effect of vitamin E on vascular endothelial cells by MODS model. The morphological changes of endothelial cells were observed and the blood levels of MDA, SOD, CAT, TXB2 and 6-K-PGFIα were detected synchronously. The results showed that the contents of MDA and TXB2 in MODS group were significantly higher than those in MODS group (P <0.01), while the levels of SOD, CAT and 6-K-PGFIα were decreased (P <0.01). Scanning and transmission electron microscopy were used to observe the significant damage and loss of normal morphology of MODS vascular endothelial cells. The above indexes of VitE group were all improved to some extent. Observations suggest that MODS animals significantly increased lipid peroxidation damage, while the anti-oxidant capacity Minnesota decreased. This change may have important pathophysiological significance in the pathogenesis of MODS. Early use of VitE on the prevention and treatment of MODS is beneficial.