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目的：探讨了骨折手术部位感染患者治疗前后血清hs-CRP，IL-18和血浆β-防御素-3水平的变化，分析其与骨折手术部位感染的危险性相关性。方法：应用免疫比浊法，酶联法对20例骨折手术部位感染患者进行了治疗前后血清h s-C R P，I L-18和血浆β-防御素-3进行了水平检测，并与65名非感染患者和35名正常健康人作比较。结果：骨折手术部位感染患者在治疗前血清hs-CRP，IL-18水平非常显著地高于正常人组和手术部位无感染患者（p＜0.01），而血浆β-防御素-3水平又非常显著地低于正常人组（p＜0.01），经综合治疗3个月后则与正常人比较无显著性差异（p＞0.05），血浆β-防御素-3水平与血清hs-CRP，IL-18水平呈显著负相关（r=-0.6011，-0.6721，p＜0.01）。结论：骨折手术部位感染患者血清hs-CRP，IL-18水平的升高和血浆β-防御素-3水平的降低，可能是骨折手术部位感染的危险因素。“,”objective:To explore the Serum hs-CRP,IL-18 and plasma Beta-Defeusin-3 concentration after treatment in patients with bone fracture operative site infections and its clinical assesement .Analysis its correlation with diseases was evaluated. Methods:serum hs-CRP(with inmuno turbility method)serum IL-18 and plasma Beta-defension-3(with ELISA)levels were determined in 20 cases with bone fracture operative site infections and 65 cases without 35 controls. Results:before treatment,serum hs-CRP,IL-18 levels were significantly higher than those in controls (p<0.01),but Beta-defension-3 levels were significantly lower (p0.05) plasma Beta-defension-3 levels were negatively correlated with serum hs-CRP,IL-18 levels (r=-0.6011,-0.6721, p<0.01)conclusions:increases of hs-CRP,IL-18 and decreased Beta-defen-3 is found after bone fracture operative site infections maybe independently associated with bone fracture operative site infection.