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目的研究新生儿胆红素性脑损伤患儿血清神经元特异性烯醇化酶(serum neuron-specific enolase,sNSE)含量与血清胆红素、白蛋白及B/A值的关系。方法采用ELISA法测定高胆红素血症新生儿血清s-NSE含量,全自动生化分析仪测定其血清间接胆红素数值(UCB)、白蛋白数值(A),计算间接胆红素与白蛋白的比值(B/A);将62例sNSE含量增高患儿分成两组:s-NSE值轻度增高组和s-NSE值重度增高组,分析两组血清指标的差异,以及s-NSE值与各指标的相关性。结果两组间UCB值差异有统计学意义(P<0.05),A值无统计学意义(P>0.05),B/A值差异有统计学意义(P<0.001);s-NSE值与B/A值呈高度正相关性(r=0.687,P<0.001)。结论 B/A比值能较好的反应胆红素性脑损害,临床可通过对B/A值的监测,指导高胆红素血症患儿的合理干预。
Objective To investigate the relationship between serum neuron-specific enolase (sNSE) levels and serum bilirubin, albumin and B / A in neonates with bilirubin-induced brain injury. Methods Serum levels of s-NSE in neonates with hyperbilirubinemia were determined by ELISA. Serum indirect bilirubin (UCB) and albumin (A) values were measured by automatic biochemical analyzer. The levels of indirect bilirubin and white (B / A). Sixty-two children with increased sNSE levels were divided into two groups: mild increase in s-NSE value and severe increase in s-NSE value. Value and the relevance of each indicator. Results There was significant difference in UCB between the two groups (P <0.05), A value was not statistically significant (P> 0.05), B / A value was significantly different (P <0.001) / A value was highly positive correlation (r = 0.687, P <0.001). Conclusions The B / A ratio can better reflect the bilirubin brain damage. The B / A ratio can be monitored clinically to guide the rational intervention of hyperbilirubinemia in children.