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目的探讨冠心病患者血尿酸水平与冠状动脉病变范围及程度之间的关系,为临床早期病情评估及治疗决策选择提供依据。方法根据冠脉造影结果,将129例患者依据病变范围分为冠脉0支病变组、单支病变组、双支病变组、多支病变组(3支或3支以上);依据病变程度分为冠脉正常组、轻度狭窄组、中度狭窄组、重度狭窄组、完全闭塞组,分别统计每组患者血尿酸水平,并做统计学分析及前瞻性研究。结果血尿酸水平:冠脉0支病变组(330±70)μmol/L、单支病变组(370±60)μmol/L、双支病变组(470±70)μmol/L、多支病变组(490±50)μmol/L;冠脉正常组(330±70)μmol/L、轻度狭窄组(370±50)μmol/L、中度狭窄组(470±40)μmol/L、重度狭窄组(490±50)μmol/L、完全闭塞组(450±60)μmol/L,即随冠状动脉病变范围扩大或和狭窄程度增加,血尿酸水平逐渐升高(P<0.05)。结论血尿酸水平高低可作为临床观察和评定冠脉病变发展(病变范围或和狭窄程度)的指标。
Objective To investigate the relationship between serum uric acid level and the extent and extent of coronary artery disease in patients with coronary heart disease, and to provide evidence for the assessment of early clinical conditions and the choice of treatment decision. Methods According to the results of coronary angiography, 129 patients were divided into 0 coronary lesion group, single lesion group, double-vessel lesion group and multi-vessel lesion group (3 or more) according to the extent of lesion. According to the degree of lesion For the normal coronary artery group, mild stenosis group, moderate stenosis group, severe stenosis group and complete occlusion group, the level of serum uric acid in each group was calculated. Statistical analysis and prospective study were performed. Results Serum uric acid levels were significantly higher in patients with 0 coronary artery disease than those with coronary artery disease (330 ± 70 μmol / L, 370 ± 60 μmol / L, 470 ± 70 μmol / L, (490 ± 50) μmol / L in normal group, 330 ± 70 μmol / L in normal coronary artery group, 370 ± 50 μmol / L in mild stenosis group and 470 ± 40 μmol / L in moderate stenosis group, (490 ± 50) μmol / L, and complete occlusion group (450 ± 60) μmol / L. The level of serum uric acid gradually increased with the extent of coronary artery stenosis and stenosis (P <0.05). Conclusion The level of serum uric acid can be used as an index for clinical observation and assessment of the development of coronary lesions (extent of lesions or degree of stenosis).