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目的探讨重度有机磷中毒并发多器官功能衰竭的发病机制、临床特点和治疗措施。方法回顾性分析54例重度有机磷中毒并发多器官功能衰竭患者的临床资料。结果所有患者均在24h内发病,累及最多的是脑和呼吸系统。54例中死亡17例,总死亡率为31.49%。结论多器官功能衰竭是有机磷中毒常见并发症和死亡的主要原因,合理采取综合救治策略是降低病死率的关键。
Objective To investigate the pathogenesis, clinical features and treatment of severe organophosphorus poisoning complicated by multiple organ failure. Methods The clinical data of 54 patients with severe organophosphorus poisoning complicated with multiple organ failure were retrospectively analyzed. Results All patients developed morbidity within 24 hours, with the most affected being the brain and respiratory system. Of the 54 patients, 17 died, with a total mortality rate of 31.49%. Conclusions Multiple organ failure is the main reason for the common complication and death of organophosphate poisoning. The rational strategy of comprehensive treatment is the key to reduce the mortality.