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目的通过对40例2型糖尿病患者采用不同胰岛素强化治疗,探讨最佳胰岛素强化治疗方法。方法将40例随机血糖>17.0mmol/L的2型糖尿病患者随机分为胰岛素泵组(CSⅡ)20例,多次皮下注射胰岛素组(M SⅡ)20例,观察两组患者治疗前后各项临床指标变化。结果经治疗两组患者血糖均明显下降,空腹血糖比较无统计学差异(P>0.05),但餐后2小时血糖CSⅡ组明显优于MSⅡ组(P<0.01),CSⅡ组患者每日胰岛素用量少于MSⅡ组(P<0.01),血糖达标所需时间少于MSⅡ组(P<0.01),平均住院天数较MSⅡ组缩短(P>0.05),两组均无严重低血糖事件发生(P>0.05)。结论诺和锐胰岛素泵治疗更符合正常人体胰岛素生理分泌模式,可以更迅速、有效的控制高血糖,胰岛素用量显著减少,低血糖发生率低,在2型糖尿病强化治疗上更具优势。
Objective To explore the optimal insulin therapy by using different insulin intensified therapy in 40 patients with type 2 diabetes mellitus. Methods Twenty patients with type 2 diabetes mellitus with blood glucose> 17.0mmol / L were randomly divided into insulin pump group (CS Ⅱ) 20 cases and multiple subcutaneous injection of insulin group (M S Ⅱ) 20 cases. Before and after treatment, Indicator changes. Results The blood glucose of the two groups were significantly decreased, but there was no significant difference between the two groups (P> 0.05). However, the levels of blood glucose in the two groups at 2 hours postprandial were significantly higher than those in the MSⅡ group (P <0.01) (P <0.01). The time required for reaching the blood glucose level was shorter than that in MSⅡ group (P <0.01), and the average length of hospital stay was shorter than that in MSⅡ group (P> 0.05). There was no severe hypoglycemic event in both groups > 0.05). Conclusion Novo Rui insulin pump treatment more in line with normal physiological patterns of insulin secretion can be more rapid and effective control of hyperglycemia, a significant reduction in the amount of insulin, low incidence of hypoglycemia, intensive treatment of type 2 diabetes more advantages.