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吡丁醇(pirbuterol)是具有扩张血管及正性肌力作用的β_2肾上腺素能兴奋剂。作者应用该药长期治疗63例严重慢性心力衰竭(心衰)患者,报道其对症状、血流动力学及运动耐量的研究结果。 63例患者中男性55例,女性8例,年龄37～73(平均60)岁。心衰病因中冠心病50例,充血性心肌病11例,主动脉瓣换瓣术后左心功能减退2例。心功能Ⅳ级者12例,Ⅲ级者43例,Ⅱ级者8例。全部病例X线显示心脏扩大,肺静脉充血。均需利尿治疗。56例窦性心律中的26例以及7例房颤病人均用地高辛治疗。吡丁醇每日3次,每次20mg。治疗前及治疗期间每月临床检查,并作胸片、心电图、血液学及生化测定,记录药物副作用。不另加
Pirbuterol is a β 2 adrenergic agonist with dilation of blood vessels and positive inotropic effects. The application of the drug long-term treatment of 63 cases of severe heart failure patients with chronic heart failure, reported its symptoms, hemodynamics and exercise tolerance results. Among the 63 patients, 55 were male and 8 were female, ranging in age from 37 to 73 (mean, 60) years. Etiology of heart failure in 50 cases of coronary heart disease, congestive cardiomyopathy in 11 cases, aortic valve flap surgery left ventricular dysfunction in 2 cases. There were 12 patients with grade Ⅳ, 43 patients with grade Ⅲ and 8 patients with grade Ⅱ. All cases of X-ray showed enlarged heart, pulmonary venous congestion. Needs diuretic treatment. 26 of 56 patients with sinus rhythm and 7 patients with atrial fibrillation were treated with digoxin. Pirin 3 times a day, each 20mg. Before treatment and during the monthly clinical examination, and for chest radiography, electrocardiogram, hematology and biochemical tests, record drug side effects. No additional