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用ｒａｓＰ２１单克隆抗体和免疫组化ＳＰ法，对３６例乳腺癌及其癌旁组织进行检测，按Ｂｌｏｏｍ改良组织学分组法进行分级，结果显示：癌组织分级意高，ｒａｓＰ２１表达愈强，其阳性率亦愈高。在乳腺癌癌旁组织中，细胞增生活跃且与癌组织有移行者ｒａｓ有弱阳性表达。本研究提示在乳腺癌中，突变的ｒａｓＰ２１表达增强，持续传递细胞增生信息，可做为乳腺癌增生程度及预后的一个指标。
Using rasP21 monoclonal antibody and immunohistochemical SP method, 36 cases of breast cancer and its adjacent tissues were detected and ranked according to the Bloom modified histological grouping method. The results showed that the cancer tissue was highly graded and the expression of rasP21 was stronger. The higher the positive rate is. In breast cancer adjacent tissues, cell proliferation was active and there was weak positive expression of ras in transitional cancer tissue. This study suggests that in breast cancer, increased expression of rasP21 mutations, continuous transmission of cell proliferation information, can be used as an indicator of breast cancer hyperplasia and prognosis.