非霍奇金淋巴瘤染色体异常与组织学及免疫学表型相关性的探讨

• 作 者: 李晓莉 韩传贵 李丽
• 出 处: 白血病
• 发表日期: 1996年01期
• 关键词: 非霍奇金淋巴瘤 染色体异常 组织学分类 免疫学分型 短期培养法 染色体结构 超二倍体 免疫学表型 亚二倍体 核型分析

应用短期培养法对２４例非霍奇金淋巴瘤（ＮＨＬ）进行核型分析，同时对该组病例进行免疫学分型和组织学分类。２４例ＮＨＬ除１例无分裂相外，均出现克隆性染色体异常，数目异常主要是亚二倍体，超二倍体、四倍体；数目的丢失、获得是非随机的，６ｑ－最多见，主要见于ＳＬ、ＤＬ、ＩＢＬ；１４ｑ＋多见，主要见于ＳＬ、ＤＬ及ＬＢＬ，同时与供体不同有关。Ｔ细胞淋巴瘤多见１４、７、６、１２、１９号染色体异常，Ｂ细胞淋巴瘤可见ｔ（１４，１８）（ｑ３２，ｑ２１）

Short-term culture method was used to analyze the karyotype of 24 cases of non-Hodgkin’s lymphoma (NHL). At the same time, immunophenotyping and histological classification were performed in this group of cases. Twenty-four cases of NHL had clonal chromosome abnormalities except 1 case with no splitting phase. The abnormal numbers were mainly hypodiploid, hyperdiploid and tetraploid; the number of loss and gain was non-random, and 6q-the most common. Mainly found in SL, DL, IBL; 14q + more common, mainly seen in SL, DL and LBL, and different from the donor. T cell lymphomas are more common in chromosomes 14, 7, 6, 12, and 19, B-cell lymphomas are seen in t(14,18)(q32,q21)