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神经炎症是神经退行性疾病的病因之一,也是重要的诱发因素。抑制脑部神经的炎症,有益于神经退行性疾病的预防与治疗。脑内胶质细胞的激活是神经炎症的主要表现,也是诱导型一氧化氮合酶(iNOS)活化的诱因。近年研究表明,多种天然产物能够抑制脑内胶质细胞的激活,具有良好抗神经炎症活性,成为神经退行性疾病的潜在治疗药物,作用机制涉及抑制NO释放、核转录因子-κB(NF-κB)等。根据近年来文献报道,归纳和总结了具有抗神经炎症生物活性的天然产物的结构及其作用机制,为从天然产物中筛选抗神经炎症和治疗神经退行性疾病药物提供一定的思路和依据。
Neuroinflammation is one of the causes of neurodegenerative diseases and is also an important predisposing factor. Inhibit the inflammation of the brain nerve, beneficial for the prevention and treatment of neurodegenerative diseases. Activation of glial cells in the brain is a major manifestation of neuroinflammation and an inducer of inducible nitric oxide synthase (iNOS) activation. Recent studies have shown that a variety of natural products can inhibit the activation of glial cells in the brain, has good anti-neuroinflammatory activity, a potential therapeutic drug for neurodegenerative diseases, the mechanism involves inhibition of NO release, nuclear factor-κB (NF- κB) and so on. According to reports in recent years, the structure and mechanism of natural products with biological activity of anti-neuroinflammation are summarized and summarized, which provide some ideas and bases for screening anti-neuroinflammation and treating neurodegenerative diseases from natural products.