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目的观察丹红注射液联合低分子肝素对慢性阻塞性肺疾病急性加重期(AECOPD)血液流变学、血气分析及肺功能的影响。方法 60例AECOPD患者随机分为治疗组(30例)和对照组(30例)。对照组予常规治疗,治疗组在常规治疗的基础上加用丹红注射液和低分子肝素。2组疗程均为10d。分别检测2组治疗前后血液流变学、血气分析及肺功能指标,并比较2组的临床疗效。结果治疗组与对照组的临床总有效率分别为93.3%、70.0%(P<0.05)。治疗组治疗后血液流变学、血气、肺功能指标的改善均较对照组明显,与治疗前比较差异均有统计学意义(P均<0.05)。结论 AECOPD患者存在高凝状态,在常规治疗的同时给予抗凝治疗,能有效改善血液流变学、血气及肺功能指标,提高临床疗效。
Objective To observe the effect of Danhong injection combined with low molecular weight heparin on the hemorheology, blood gas analysis and pulmonary function in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty AECOPD patients were randomly divided into treatment group (30 cases) and control group (30 cases). The control group was given routine treatment. The treatment group was given Danhong injection and low molecular weight heparin on the basis of routine treatment. 2 groups of treatment are 10d. Blood rheology, blood gas analysis and lung function indexes of two groups were detected before and after treatment, and the clinical curative effect of the two groups were compared. Results The total clinical effective rates of the treatment group and the control group were 93.3% and 70.0%, respectively (P <0.05). After treatment, the improvement of hemorheology, blood gas and lung function of the treatment group was more obvious than that of the control group, and the difference was statistically significant (P <0.05). Conclusion AECOPD patients with hypercoagulable state, given conventional anticoagulant therapy, can effectively improve the hemorheology, blood gas and pulmonary function indicators to improve clinical efficacy.