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目的研究Caveolin-1的表达与肺癌临床病理学特征的相关性。方法采用免疫组织化学的方法检测肺癌穿刺组织中Caveolin-1的表达情况。结果肺癌组织中Caveolin-1阳性率明显高于正常肺组织,肺癌的组织学分类、分化程度和TNM分期与Caveolin-1呈正相关。结论 Caveolin-1的表达上调提示与肺癌有关,有可能成为诊治肺癌的关键环节。
Objective To study the correlation between the expression of Caveolin-1 and clinicopathological characteristics of lung cancer. Methods The expression of Caveolin-1 in lung cancer tissue was detected by immunohistochemistry. Results The positive rate of Caveolin-1 in lung cancer tissues was significantly higher than that in normal lung tissues. The histological classification of lung cancer and the degree of differentiation and TNM stage were positively correlated with Caveolin-1. Conclusion The up-regulation of Caveolin-1 is associated with lung cancer, which may become a key link in the diagnosis and treatment of lung cancer.