丹参抗大鼠乙酸胃溃疡和防止复发的效果

• 作 者: 王国中 茹新 丁丽华 李和泉
• 机 构: 齐齐哈尔医学院病理生理教研室,齐齐哈尔医学院第一附属医院外科
• 出 处: 华人消化杂志
• 发表日期: 1998年01期
• 关键词: 丹参 大鼠 乙酸胃溃疡

目的探讨丹参抗大鼠乙酸胃溃疡和防止复发的效果及机制．方法在大鼠乙酸胃溃疡急性期用丹参治疗，并与传统的抗溃疡药西咪替丁相对比，采用Ｋｅｒｓ等法测定胃粘膜表面凝胶厚度，应用传统的体外掺入氚胸腺嘧啶（３ＨＴｄＲ）于胃粘膜的放射性自显影方法测定胃粘膜细胞的标记率（ＬＲ），同时观测ｄ５、ｄ３０、ｄ１２６的溃疡指数（ＵＩ）、溃疡抑制率（ＩＲ）与凝胶的厚度、ＬＲ的关系．结果丹参组的ＵＩ低于西咪替丁组（４２３±３９，３６±１２，４４±２３；４９１±３６，５９±１４，９２±１３，Ｐ＜００１）；西咪替丁组的低于对照组（６１０±３８，８９±２５，１２４±２４，Ｐ＜００１）；丹参组的ＩＲ（％）高于西咪替丁组（３１，５９，６５；１９，３３，２６）；丹参组的凝胶厚度（μｍ）高于西咪替丁组（４５±３，６０±３，５８±２；３６±４，４７±４，４１±３，Ｐ＜００１），西咪替丁组的高于对照组（２２±６，３５±３，２８±５，Ｐ＜００１）；丹参组的ＬＲ（％）高于西咪替丁组（１００±０５，１６２±０８，１５０±０６；９０±０５，１３９±０６，１０８±０７，Ｐ＜００１）、西咪替?

Objective To investigate the effect and mechanism of salvia miltiorrhiza on gastric ulcer in rats and prevention of recurrence. Methods Salvia miltiorrhiza was used in the acute stage of acetic acid-induced gastric ulcer in rats. Compared with the traditional anti-ulcer drug cimetidine, the gel thickness of gastric mucosa was determined by Kers et al. The traditional in vitro mixed tritiated thymidine 3H-TdR) in gastric mucosa. The ulceration index (UI), ulceration inhibition (IR) and gel thickness of d5, d30 and d126 were also measured. Relationship. Results The UI of Salvia miltiorrhiza group was lower than that of cimetidine group (423 ± 39, 36 ± 12, 44 ± 23; 491 ± 36, 59 ± 1  4,9  2 ± 1  3, P <0  01). The cimetidine group was lower than the control group (610 ± 38, 89 ± 25, 124 ± 2  4, P <001). IR of Salvia miltiorrhiza group was higher than that of cimetidine group (31,59,65; 19,33,26). Salvia miltiorrhiza group had higher gel thickness (μm) Cimetidine group (45 ± 3,60 ± 3,58 ± 2; 36 ± 4,47 ± 4,41 ± 3, P <001), cimetidine group was higher than the control group (22 ± 6 , 35 ± 3,28 ± 5, P <001). LR (%) in salvia miltiorrhiza group was higher than that in cimetidine group (100 ± 05, 162 ± 08, 150 ± 06; 90 ± 05, 139 ± 06, 108 ± 07, P <001), cimetidine