论文部分内容阅读
采用酸性非特异性酯酶(ANAE)方法,对不同甲状腺机能状态下大鼠细胞免疫水平进行了观察 动物分为三组:实验性甲状腺机能低下组(甲低组);实验性甲状腺机能亢进组(甲亢组);对照组为正常大鼠,不做任何处理。结果表明:①正常大鼠外周血淋巴细胞的ANAE阳性率为65.6±2.3％,甲低组为43.6±3.9％(P<0.01),甲亢组为66.2±1.9％(P>0.05)。②与对照组相比,甲低级脾动脉周围淋巴鞘和脾小体,淋巴结的副皮质区和淋巴小结,胸腺皮质和髓质等区域的 ANAE阳性淋巴细胞百分率降低,甲亢组无明显变化。结果提示他巴唑能明显抑制大鼠的细胞免疫功能。
The level of cellular immunity in rats with different thyroid function status was observed by using ANAE method. The animals were divided into three groups: experimental hypothyroidism group (hypothyroidism group), experimental hypothyroidism group (hypothyroidism group) Hyperthyroidism group); the control group was normal rats, without any treatment. The results showed that: ① The positive rate of ANAE in peripheral blood lymphocytes of normal rats was 65.6 ± 2.3%, that of hypothyroidism was 43.6 ± 3.9% (P <0.01), and that of hyperthyroidism was 66.2 ± 1.9% (P> 0.05). ② Compared with the control group, the percentage of ANAE-positive lymphocytes in lymph nodes and splenic bodies around the lower splenic artery, paracortex, lymph node, thymus cortex and medulla of lymph node decreased, but there was no significant change in hyperthyroidism group. The results suggest that methimazole can significantly inhibit the cellular immune function in rats.