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致命的系统性红斑狼疮病人往往需要大剂量皮质类固醇和细胞毒性或细胞抑制性药物治疗。但迄今有关甲基泼尼松龙单用或甲基泼尼松龙和环磷酸胺联合应用治疗狼疮性肾炎的疗效和毒性反应还未十分清楚。作者进行了追踪至少5年的随机对照试验，旨在明确：①大剂量甲基泼尼松龙治疗是
Deadly systemic lupus erythematosus patients often require high-dose corticosteroids and cytotoxic or cytostatic drugs. However, the efficacy and toxicity of methylprednisolone or methylprednisolone combined with cyclophosphamide in the treatment of lupus nephritis so far have not yet been fully elucidated. The authors conducted randomized controlled trials that tracked at least 5 years to identify: (i) high-dose methylprednisolone treatment