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目的:研究急性脑梗死患者血清中补体末端复合体(TCC)含量与脑梗死体积及预后的关系。方法:98例急性脑梗死患者(病例组)及95例健康对照者(对照组)来自山东大学附属省立医院,病例组患者均于出现症状24h内入组。在确诊当时及第1、2、3、4、6、10天各留取血液标本1次,测定血清TCC水平。梗死体积为第7天CT经Simes Somatom所提供的软件测得。神经功能恢复评定标准为修正的Rankin等级评分。结果:(1)病例组卒中发作初期血浆TCC含量与对照组差异无显著性,48hTCC含量明显增加,到第6天达到最高,第10天仍高。(2)血清TCC含量与脑梗死体积及Rankin等级评分有相关性。结论:(1)急性脑梗死后补体激活参与了卒中后炎症反应。(2)TCC含量与梗死体积及患者预后密切相关,能反映卒中时脑组织的损害程度,可以作为脑梗死患者简单易行、价廉有效的预测指标。
Objective: To study the relationship between the serum level of complement terminal complex (TCC) and the volume and prognosis of cerebral infarction in patients with acute cerebral infarction. Methods: A total of 98 patients with acute cerebral infarction (case group) and 95 healthy controls (control group) were from Provincial Hospital Affiliated to Shandong University. Patients in the case group were enrolled within 24 hours after symptom onset. At the time of diagnosis and on the 1st, 2nd, 3rd, 4th, 6th and 10th days respectively, the blood samples were collected and the level of serum TCC was measured. The infarct volume was day 7 CT, as measured by software provided by Simes Somatom. The assessment of neurological function was revised Rankin grade. Results: (1) There was no significant difference in plasma TCC levels between the two groups at the beginning of stroke onset. The content of TTC increased significantly at 48h, reaching the highest on the 6th day and remained high on the 10th day. (2) There was a correlation between serum TCC level and cerebral infarction volume and Rankin grade score. Conclusion: (1) Complement activation after acute cerebral infarction is involved in the post-stroke inflammatory response. (2) TCC content is closely related to infarction volume and patient prognosis, can reflect the degree of brain damage during stroke, and can be used as a simple, inexpensive and effective prediction index for patients with cerebral infarction.