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目的探讨血浆1,3-β-D葡聚糖检测(G试验)结果在侵袭性真菌感染(IFI)中的诊断意义。方法应用MB-80微生物动态快速检测系统及GKT一1M动态真菌检测试剂盒定量检测血浆1,3-β-D葡聚糖的含量,并与真菌培养法相比较。结果 340例临床患者G试验检测结果在以﹤10 pg/ml为阴性、﹥20 pg/ml为阳性阈值时,其敏感性和特异性分别为81.50%、90.42%,阳性预测值和阴性预测值分别为82.51%、89.81%,244例临床患者G试验阳性时真菌培养阳性率为62.42%,两者比较差异有统计学意义(χ2=76.934,P﹤0.001)。结论血浆1,3-β-D葡聚糖检测在诊断深部真菌感染方面具有较高的敏感性和特异性,其检测结果明显优于真菌培养法,在IFI临床诊断中具有较好的一致性;是诊断IFI的可靠方法。
Objective To investigate the diagnostic value of plasma 1,3-β-D-glucan test (G test) in invasive fungal infection (IFI). Methods MB-80 microbial rapid test system and GKT-1M dynamic fungi detection kit were used to quantitatively detect the plasma 1,3-β-D glucan content and compared with the fungal culture method. Results The sensitivity and specificity of the G test in 340 patients were 81.50% and 90.42%, respectively. The positive and negative predictive value of negative predictive value was <10 pg / ml and> 20 pg / Respectively, 82.51% and 89.81% respectively. The positive rate of fungal culture in 244 clinical positive patients with G test was 62.42%. There was significant difference between the two (χ2 = 76.934, P <0.001). Conclusion The detection of plasma 1,3-β-D-glucan has high sensitivity and specificity in the diagnosis of deep fungal infection. The detection results are obviously superior to those of fungal culture and have good consistency in the clinical diagnosis of IFI ; Is a reliable way to diagnose IFI.