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目的动态观察慢性乙型肝炎患者急性发作后血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)和血清免疫球蛋白G(IgG)等指标,探讨慢性乙型肝炎急性发作后宿主肝功能损伤和体液免疫动态变化间的关系。方法随机选取16例HBc-IgM阳性慢性乙型肝炎患者为实验组,16例HBc-IgM阴性者为对照组,分别检测其血清ALT、AST和IgG,31(30.80±12.60)d后第二次检测HBc-IgM阳性组患者的上述指标。结果①HBc-IgM阳性组患者血清ALT、AST和IgG均高于HBc-IgM阴性组,两组间有显著性差异(P<0.05)。②HBc-IgM阳性患者血清ALT和AST第一次测定结果高于第二次,两组间有显著性差异(P<0.05);血清免疫球蛋白G第一次检测结果与第二次相比无显著性差异(P>0.05)。③HBc-IgM阳性组患者血清IgG第二次测定结果高于HBc-IgM阴性组,两组间有显著性差异(P<0.05)。结论慢性乙型肝炎急性发作后,患者血清IgG水平和转氨酶升降一致,血清IgG水平对于判断慢性乙型肝炎患者肝内活动性病变有一定临床意义。
Objective To observe the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum immunoglobulin G (IgG) in patients with chronic hepatitis B before and after acute exacerbation of chronic hepatitis B Relationship between host liver function impairment and humoral immune changes after the onset of stroke. Methods Totally 16 HBc-IgM positive chronic hepatitis B patients were selected as the experimental group and 16 HBc-IgM negative as the control group. Serum ALT, AST and IgG were detected in serum and 31 (30.80 ± 12.60) d The above indicators of HBc-IgM positive patients were detected. Results ① The levels of serum ALT, AST and IgG in HBc-IgM positive group were significantly higher than those in HBc-IgM negative group (P <0.05). (2) The serum ALT and AST levels in HBc-IgM positive patients were higher than those in the second, with significant difference between the two groups (P <0.05); the serum immunoglobulin G first time test results were no significant difference compared with the second time Significant difference (P> 0.05). (3) Serum IgG in HBc-IgM positive group was higher than HBc-IgM negative group in the second test, and there was significant difference between the two groups (P <0.05). Conclusions Serum IgG levels are consistent with those of transaminases after acute attack of chronic hepatitis B, and serum IgG level has some clinical significance for judging active intrahepatic lesions in patients with chronic hepatitis B.