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目的观察DEF方案(氟尿嘧啶、表柔吡星、顺铂)超选择子宫动脉化疗栓塞术后序贯放疗晚期宫颈癌的疗效,评价近期疗效。方法对46例中晚期宫颈癌患者(Ⅱb~Ⅳ期)行动脉化疗栓塞及化疗灌注术序贯放疗,观察其近期疗效、不良反应及影响疗效的因素。结果动脉化疗栓塞的总有效率为78.3%。结论该方案超选择动脉化疗栓塞的临床总有效率高,近期有效率高,不良反应小,对宫颈癌疗效确切。
Objective To observe the curative effect of DEF regimen (fluorouracil, epirubicin and cisplatin) in the treatment of advanced cervical cancer after superselective uterine artery chemoembolization and evaluate the short-term curative effect. Methods Forty-six patients with advanced cervical cancer (stage Ⅱb-Ⅳ) underwent sequential chemoradiotherapy and chemoembolization with sequential radiotherapy. The curative effect, side effects and the factors affecting the curative effect were observed. Results The total effective rate of arterial chemoembolization was 78.3%. Conclusion The superselective arterial chemoembolization has high total clinical efficiency, high efficiency recently, small adverse reaction, and definite effect on cervical cancer.