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目的探讨重度子痫前期孕妇在期待治疗中发生不良妊娠结局的危险因素。方法选择1999年1月～2009年12月在我院住院完整实施期待治疗的重度子痫前期孕妇97例,按照妊娠结局分为良好结局组29例和不良结局组68例。观察两组孕妇妊娠结局、血流动力学和血常规指标。结果良好结局组与不良结局组孕妇妊娠结局发生并发症情况比较,差异有统计学意义(P<0.05)。血流动力学与血常规检测,良好结局组全血黏度[(4.5±0.5)mPa.s]及血浆黏度[(1.58±0.05)mPa.s]明显低于不良结局组,两组比较,差异有统计学意义(P<0.05)。良好结局组孕妇血小板计数[(193±72)×109/L]明显高于不良结局组,而红细胞计数[(3.8±0.4)×1012/L]和红细胞压积明显低于不良结局组。两组比较,差异有统计学意义(P<0.05)。结论红细胞计数升高、血小板计数降低是重度子痫前期实施期待治疗过程中发生不良妊娠结局的危险因素。
Objective To explore the risk factors of adverse pregnancy outcomes in expectant treatment of severe preeclampsia. Methods Ninety-seven pregnant women with severe preeclampsia who were hospitalized in our hospital from January 1999 to December 2009 were divided into two groups according to their pregnancy outcome: 29 cases with good outcome and 68 cases with adverse outcome. Pregnancy outcomes, hemodynamics and blood parameters were observed in both groups. Results There were significant differences in the pregnancy complications between the good outcome group and the poor outcome group (P <0.05). Hemodynamics and blood tests showed that whole blood viscosity [(4.5 ± 0.5) mPa.s] and plasma viscosity [(1.58 ± 0.05) mPa.s] were significantly lower in the good outcome group than in the poor outcome group There was statistical significance (P <0.05). The platelet count of pregnant women with good outcome group was significantly higher than that of the poor outcome group [(193 ± 72) × 109 / L], while the red blood cell count [(3.8 ± 0.4) × 1012 / L] and hematocrit were significantly lower than those with poor outcome. The difference between the two groups was statistically significant (P <0.05). Conclusion The increase of erythrocyte count and the decrease of platelet count are the risk factors of adverse pregnancy outcome in the treatment of severe preeclampsia.