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目的描述结膜痣的临床特点,评价在长期病损出现的颜色和尺寸变化。设计:回顾性、观察性、非对比性病例系列。参考者:410例结膜痣的连续病例。主要结果测量:2个主要结果度量标准是肿瘤颜色和大小的变化。结果在410例患者中365(约89%)是白种人,23例(约6%)是非裔美国人,8例(约2%)是亚洲人,8例(约2%)是印第安人,6例(约1%)是西班牙裔。虹膜颜色55%(229/418)是棕色,20%(85/418)是蓝色,20%(83/418)是绿色,5%(21/418)未说明。痣的颜色65%是棕色,19%是褐色,16%完全没有色素。痣的解剖位置在球结膜的为72%(302只眼),在泪阜的占15%(61只眼),在半月皱襞的占11%(44只眼),在穹隆的占1%(6只眼),在睑板的占1%(3只眼)和在角膜的占<1%(2只眼)。球结膜病变多比邻于角巩膜缘。结膜痣的角限位置分为颞侧(190只眼,46%),鼻侧(184只眼,44%),上方(23只眼,6%)和下方(21只眼,5%)。附加的特点还有病损内囊肿(65%),供血血管(33%)和可见自身血管(38%)。囊肿在70%组织病理学检查中已经确诊为混合性结膜痣,在上皮下痣中的几率为58%,在交界性痣中为40%,在蓝色痣中为0。在149例定期随访平均11a的患者中,病变颜色逐渐变深的为5%(7例),逐渐变浅的为8%(12例),颜色不发生变化的为87%(130例)。病损尺寸有增大的为7%(10例),出现缩少的为1%(1例),?
Objective To describe the clinical features of conjunctival nevus and evaluate the color and size changes that occur in long-term lesions. Design: retrospective, observational, non-contrasting case series. Reference: 410 consecutive cases of conjunctival nevus. MAIN RESULTS MEASUREMENTS: The two primary outcome measures were changes in tumor color and size. Results Of the 410 patients, 365 (approximately 89%) were Caucasian, 23 (approximately 6%) were African American, 8 (approximately 2%) were Asian and 8 (approximately 2%) were Native American Six cases (about 1%) were Hispanic. The iris color is 55% (229/418) brown, 20% (85/418) blue, 20% (83/418) green, and 5% (21/418) unspecified. The color of the mole 65% is brown, 19% is brown, 16% is completely pigmented. The anatomical location of the moles was 72% (302 eyes) in the conjunctiva, 15% (61 eyes) in the lacridiflares, 11% (44 eyes) in half-moon folds, and 1% in the dome 6 eyes), 1% (3 eyes) of the tarsal and <1% (2 eyes) of the cornea. Bulbar conjunctival lesions more adjacent to the limbus. Conjunctival nevi were divided into temporal (190 eyes, 46%), nasal (184, 44%), upper (23, 6%) and lower (21, 5%). Additional features include lesions within the cyst (65%), blood vessels (33%) and visible autologous blood vessels (38%). Cysts have been diagnosed as mixed conjunctival nevus in 70% histopathological examination, with a 58% incidence in subepithelial nevus, 40% in borderline nevus and 0 in blue nevus. Among 149 consecutive patients with a mean follow-up of 11 years, the lesions became darker in 5% (7 cases), gradually lighter in 8% (12 cases), and unchanged in 87% (130 cases). The lesion size increased by 7% (10 cases), decreased 1% (1 case),?