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目的对大剂量尿激酶溶栓治疗急性大面积肺栓塞(PE)患者的临床疗效进行观察。方法 60例急性大面积PE患者,随机分为研究组与对照组,各30例。对照组应用常规疗法,研究组应用大剂量尿激酶溶栓治疗。比较两组的临床疗效。结果研究组治疗总有效率显著高于对照组(P<0.05);研究组的脉搏、呼吸、舒张压、收缩压、氧分压(Pa O2)、二氧化碳分压(Pa CO2)等指标均优于对照组(P<0.05)。结论应用大剂量尿激酶溶栓治疗急性大面积肺栓塞患者,能够取得显著疗效并改善临床症状,值得临床推广。
Objective To observe the clinical effect of high-dose urokinase thrombolytic therapy in patients with acute large-area pulmonary embolism (PE). Methods Sixty patients with acute large area PE were randomly divided into study group and control group, with 30 cases in each. Control group, conventional therapy, the study group used high-dose urokinase thrombolytic therapy. The clinical efficacy of the two groups was compared. Results The total effective rate of the study group was significantly higher than that of the control group (P <0.05). The pulse, respiration, diastolic blood pressure, systolic blood pressure, Pa O2 and Pa CO2 of the study group were all excellent In the control group (P <0.05). Conclusion The application of high-dose urokinase thrombolytic therapy in patients with acute large area pulmonary embolism can achieve significant effect and improve clinical symptoms, which is worthy of clinical promotion.