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本文介绍的血清碱性蛋白电泳,是一种快速,简便而经济的肿瘤筛选方法。恶性肿瘤患者血清中的碱性蛋白是与血浆γ-球蛋白形成一种复合物,在pH2.0条件下,使此复合物解离,按常法进行乙酸纤维素薄膜电泳,癌症患者在点样原点有条特异的肿瘤碱性蛋白带,正常人则无。检测300例正常人均为阴性,检测800例经临床确诊为各种恶性肿瘤患者血清,癌症总阳性率73％,101例包块和咳血待查患者SBPE结果与病理检查证实为癌症的阳性符合率78.7％,测定1409例各种良性疾病,假阳性9.8％。
The serum alkaline protein electrophoresis described in this article is a rapid, simple and economic method for tumor screening. The basic protein in the serum of malignant tumor patients forms a complex with plasma γ-globulin. Under the condition of pH 2.0, the complex is dissociated and the cellulose acetate film electrophoresis is performed according to a common method, and the cancer patients are at the point. There is a band of tumor-specific alkaline protein bands at the origin of the sample, but no normal person. Detection of 300 cases of normal people were negative, detected 800 cases of clinically diagnosed with a variety of malignant tumor serum, the total positive rate of cancer was 73%, 101 cases of mass and hemoptysis patients SBPE results and pathological examination confirmed positive for cancer The rate was 78.7%, 1409 cases of various benign diseases were measured, and false positive rate was 9.8%.