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目前,国内外不同实验室采用的正常小鼠SRC法检测化疗药物敏感标准,差异甚大。对其测定的准确性和临床符合率不无影响。本文根据我室1986年8月～1989年6月间,测定女性乳腺癌对化疗药物敏感性64例为资料,研究如何规定SRC法中化疗药物敏感标准更为合理。方法学:(1)将全部实验数据输入微机,计算每例的△TS值、消退率和P值;(2)按17种标准,计算在每个标准下对每种药物的敏感率;(3)得出的結果与已知每种药物的有效率比较,并进行统计学处理。结果发现:(1)女性乳腺癌对化疗药物的敏感率,随评价标准不同而发生变化,规定的标准高(严),敏感率低,反之则高;(2)当采用P+|15％|的标准时,与临床已知的结果相一致,R=0.8,V=4,P<0.05。因此,通过本分析,采用P+|15％|标准时,较为合理。
At present, the normal mouse SRC method used in different laboratories at home and abroad to detect chemotherapeutic drug sensitive standards, the difference is very large. Its accuracy and clinical compliance rate have no effect. This article based on our room from August 1986 to June 1989, the determination of female breast cancer sensitivity to chemotherapeutic drugs in 64 cases as data, study how to set the SRC method in chemotherapy drug sensitivity standards more reasonable. Methodology: (1) Enter all the experimental data into the computer to calculate the ΔTS value, extinction rate and P value of each case; (2) calculate the sensitivity rate of each drug under each standard according to 17 criteria; ( 3) The results obtained are compared with the known effective rates for each drug and statistically processed. The results showed that: (1) The sensitivity rate of female breast cancer to chemotherapeutic drugs varies with different evaluation criteria. The prescribed standard is high (strict), and the sensitivity rate is low; otherwise, it is high; (2) When P+|15% is used | The standard was consistent with the clinically known results, R=0.8, V=4, P<0.05. Therefore, through this analysis, it is more reasonable to use the P+|15%|standard.