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强心甙的研究仍然是临床与实验室的一项富有吸引力的课题。本文着重综述强心甙基础药理学和临床药理学的一些基本概念与研究进展,特别是使洋地黄甙的临床应用能够更为合理。洋地黄作用的亚细胞机理正性收缩能作用关于强心甙正性收缩能作用的任何完整的说法,必需能解释下述基本观察结果:(1)强心甙对心肌有正性收缩能作用,对骨胳肌则无,(2)正性收缩能作用的强度取决于收缩的频率,在最佳值的二侧,增强的程度逐渐减小,(3)正性收缩能作用的强度和起始速度取决于一系列阳离子的浓度,包括钾、钠、钙和镁。虽然强心甙在中毒剂量时,能使心脏中的交感神经活力增加,但许多研究未能发现心肌儿茶酚胺含量与强心甙效应之间有密
Studies of cardiac glycosides are still an attractive topic in clinical and laboratory settings. This article focuses on some basic concepts and research progress of basic pharmacology and clinical pharmacology of cardiac glycosides, especially making the clinical application of digitalis more reasonable. Subcellular mechanism of digitalis Action positive systolic effect Any complete statement about the role of positive cardiac glycosylation can explain the following basic observations: (1) cardiac glycosides have a positive systolic effect on the myocardium (2) The intensity of positive systolic action depends on the frequency of systole, and on both sides of the optimal value, the degree of augmentation decreases gradually. (3) The intensity of the positive systolic effect and The initial speed depends on the concentration of a series of cations, including potassium, sodium, calcium and magnesium. Although cardiac glycosides in the toxic dose, can make the heart of the sympathetic activity increased, but many studies failed to find the myocardial catecholamine content and the effect of cardiac glycosides between dense